A quick trip to the local games store and we're in business! It was a no-brainer connecting the Wiimote to the PC. The only gotcha being that the Wiimote does not automatically connect to the PC after a reboot.
The next step was to find some software to translate the Wiimote's movements and clicks into mouse movements and clicks. A quick Google search yielded GlovePIE as glue I needed. Originally intended to be used with VR gloves it supports inputs from the Wiimote (and Nunchuk addon) but also a whole raft of other controllers including joysticks.
End of Part I